South Africa has launched a new twice-yearly HIV prevention injection that could significantly impact the epidemic. However, funding shortfalls and limited doses pose a threat to its widespread effectiveness.

A new twice-yearly HIV prevention injection could transform South Africa's fight against the epidemic — but U.S. aid cuts and limited doses threaten to slow its impact. <img alt="Nurse Mpho Matloane prepares a syringe filled with the drug Lenacapavir which he prepares to administer to Kegoratile Aphane (left) at the Phedisong clinic in Ga-Rankuwa, north-west of Pretoria, on Dec. 2, 2025." src="https://npr.brightspotcdn.com/dims3/default/strip/false/crop/6000x4000+0+0/resize/6000x4000!/?url=http...